Infertility is a major issue for about 12 to 15 percent of couples in the world. Out of this, almost 50 percent of them suffer from infertility due to male factors, such as poor sperm quality, low sperm count, and mortility. The poor quality of sperm is assessed by employing an advanced diagnostic test called the DNA Fragmentation Index (DFI). The DFI test has proven itself to be rather helpful in the field of assisted reproductive technology for couples aspiring to be parents in overcoming difficulties with conceiving.  DNA fragmentation can cause an alteration in the genetic make up of your sperm, leading to severe damage. This can, in turn, cause infertility in men and become a hurdle in impregnation. The DFI test provides an in depth prognosis that reaches beyond the traditional ways of assessing the quality of the sperm. Fragmented sperm can also be a reason for great stress and an overwhelming feeling of grief in couples struggling with prevalent failures in conception or unexplained miscarriages.